Cloned (Comment) | Organism |
---|---|
overexpression in human hepatocarcinoma SMMC-7721 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | autophosphorylation of epidermal growth factor receptor, EGFR, and phosphorylation of protein kinase B, PKB/Akt, and extracellular signalregulated protein kinase1/2,ERK1/2, which are downstream molecules of EGFR, are reduced in cell surface beta1,4GT1-overexpressing SMMC-7721 cells, phenotype, overview, knockdown of beta1,4GT1 by siRNA increases the autophosphorylation of EGFR at Tyr1068 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the cell surface enzyme promotes apoptosis by inhibiting the epidermal growth factor receptor pathway via inhibition of the autophosphorylation of epidermal growth factor receptor especially at Try 1068, mechanism, overview | ? | - |
? | |
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | Homo sapiens | - |
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the cell surface enzyme promotes apoptosis by inhibiting the epidermal growth factor receptor pathway via inhibition of the autophosphorylation of epidermal growth factor receptor especially at Try 1068, mechanism, overview | Homo sapiens | ? | - |
? | |
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | - |
Homo sapiens | UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta 1,4-galactosyltransferase 1 | - |
Homo sapiens |
beta1,4GT1 | - |
Homo sapiens |